The concomitant usage of tramadol hydrochloride and CYP2D6 inhibitors may cause a rise in the plasma concentration of tramadol and a lessen inside the plasma focus of M1, notably when an inhibitor is extra following a secure dose of tramadol hydrochloride is reached. Given that M1 is a far more strong μ-opioid agonist, diminished M1 exposure could
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